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High prevalence of GB-C/hepatitis G virus in a Brazilian population with helminth infection

✍ Scribed by Gallian, P.; Rodrigues, V.; Cantaloube, J. F.; Dessein, H.; de Micco, P.; Dessein, A. J.; de Lamballerie, X.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 139 KB
Volume: 56
Category: Article
ISSN: 0146-6615
DOI: 10.1002/(sici)1096-9071(199812)56:4<310::aid-jmv4>3.0.co;2-4

No coin nor oath required. For personal study only.

✦ Synopsis

A study of GB-C virus/Hepatitis G virus (GBV-C/ HGV) infection was carried out in a rural population of Northeastern Brazil, in which the prevalence of schistosomiasis is 80-90%. Despite the absence of parenteral risk exposure, the prevalence of GBV-C/HGV markers of infection was found to be unusually increased: viremia, 16.4%; specific antibody, 18.3%. It is therefore suspected that helminth infection influenced the immune response to GBV-C/HGV infection by shifting the balance of cytokine responses from Th1 to Th2, resulting in a delayed viral clearance. Phylogenetic analysis of viral isolates did not provide evidence for high rates of sexual or mother-to-infant viral transmission. The study revealed that viral strains belonged to types 1 and 2 only (predominant in Africa and Europe, respectively), suggesting that GBV-C/HGV was introduced into the New World by white conquerors and black slaves since the 16th century.

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