High pressure promoted (2+2) cycloadditions of ketene acetals with carbonyl compounds
✍ Scribed by René W.M. Aben; Hans W. Scheeren
- Book ID
- 104219947
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 264 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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## Abstract 2,2‐Dialkoxy‐3,4‐dihydropyrans (3) can be obtained under mild conditions and in good yields from ketene acetals (1) and α,β‐unsaturated carbonyl compounds (**2**) in the presence of ZnCl~2~. At low temperatures (< −20°C) the reaction between **1** and **2** proceeds as a (2 + 2)‐cycload
The high-pressure promoted cycloadditions of enol ethers (1) and alkyl 3-aryl-2-cyano-2-propenoates (2) lead stereoselectively in high yields to 2,6-dialkoxy-4-aryl-3,4-dihydro-2Hpyran-5-carbonitriles (3). These cycloadducts have a high potential for further synthesis due to the presence of various