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High pressure promoted (2+2) cycloadditions of ketene acetals with carbonyl compounds

✍ Scribed by René W.M. Aben; Hans W. Scheeren


Book ID
104219947
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
264 KB
Volume
24
Category
Article
ISSN
0040-4039

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ZnCl2-catalysed cycloadditions between k
✍ C. G. Bakker; J. W. Scheeren; R. J. F. Nivard 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 665 KB

## Abstract 2,2‐Dialkoxy‐3,4‐dihydropyrans (3) can be obtained under mild conditions and in good yields from ketene acetals (1) and α,β‐unsaturated carbonyl compounds (**2**) in the presence of ZnCl~2~. At low temperatures (< −20°C) the reaction between **1** and **2** proceeds as a (2 + 2)‐cycload

High-Pressure Promoted Cycloadditions of
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The high-pressure promoted cycloadditions of enol ethers (1) and alkyl 3-aryl-2-cyano-2-propenoates (2) lead stereoselectively in high yields to 2,6-dialkoxy-4-aryl-3,4-dihydro-2Hpyran-5-carbonitriles (3). These cycloadducts have a high potential for further synthesis due to the presence of various