High Pressure Organic Synthesis

✍ Scribed by Margetić D.

• Publisher: Walter de Gruyter
• Year: 2019
• Tongue: English
• Leaves: 263
• Category: Library

✦ Synopsis

High pressure chemistry is a widely used methodology in organic synthesis which helps to increase the rate and to improve the efficiency of chemical processes. The current publication outlines the impact of pressure on many types of chemical reactions important from synthetic point of view and gives practical considerations how to plan and perform synthetic experiments under high pressure in the lab.
Gives an overview of recent developments in the field.
Explains the possibilities to reduce reaction times, increase yields and improve regio- and stereoselectivity applying high pressure.
Contains numerous examples of natural product syntheses.

✦ Table of Contents

Cover
Half Title
Also of interest
High Pressure Organic Synthesis
Copyright
Dedication
Preface
Contents
Abbreviations
1. Introduction
1.1 Historical background
1.2 Basic physicochemical principles
1.3 Technical details (equipment)
1.3.1 Piston-cylinder apparatus
1.3.2 HP solvents
1.4 Quantum–chemical calculations
References
2. Diels–Alder cycloaddition reactions
Introduction
2.1 DA cycloaddition reactions
2.2 Heterocyclic dienes
2.2.1 Five-membered dienes
2.2.1.1 Furan
2.2.1.2 Pyrrole
2.2.1.3 Thiophene
2.2.1.4 Siloles
2.2.1.5 Oxazoles
2.2.2 Six-membered dienes
2.2.2.1 Pyrones
2.2.2.2 Pyridone
2.2.2.3 Tetrazines
2.3 HDA reactions
2.4 Intramolecular DA reactions
2.5 RDA reactions
2.6 Homo-Diels–Alder reactions
2.7 Tandem DA reactions
2.8 Selectivities of DA reactions
2.9 Asymmetric reactions
2.10 Natural product synthesis
2.11 DA reactions of fullerenes
References
3. 1,3-Dipolar cycloaddition reactions
3.1 Azides
3.2 Diazo compounds
3.3 Nitrones
3.4 Nitrile oxides
References
4. C–C bonds
4.1 Aldol condensation
4.2 Knoevenagel reaction
4.3 Cope rearrangement
4.4 Michael reaction
4.5 Conjugate additions
4.6 Morita–Baylis–Hillman reaction
4.7 Friedel–Crafts reaction
4.8 Palladium catalyzed coupling reactions
4.9 Cycloaddition reactions
4.9.1 [2+2] Cycloaddition reactions
4.9.2 [4+4] Cycloadditions
4.9.3 [6+4] and [8+2] Cycloadditions
4.10 Wittig reaction
4.11 Ene reaction
4.12 Condensation and polymerization reactions
4.13 Organotin reactions
References
5. C–N bonds
5.1 Menshutkin reaction
5.1.1 N-Alkylation
5.2 Formation of peptide/amide bonds
5.2.1 Peptide coupling
5.2.2 Aminolysis of esters
5.2.3 Transamidation
5.2.4 [2 + 2] cycloaddition
5.3 Aza-Michael reaction
5.4 Functional transformations of carboxylic acid derivatives
5.5 Miscellaneous reactions
References
6. C–O, C–S and other bonds
Introduction
6.1 C–O bonds
6.1.1 Ethers
6.1.2 Esters
6.1.3 Alcohols
6.2 C–S bond
6.3 C–Sn bond
6.4 C–Si bond
6.5 C–Se bond
6.6 C–B bond
6.7 C–P bonds
6.8 C–Halogen bonds
6.9 C–Metal bond
6.10 O–O bond
References
7. Oxidation and reduction reactions
7.1 Oxidation reactions
7.2 Reduction reactions
References
8. Multicomponent reactions
References
9. Supramolecular chemistry
References
10. Miscellaneous reactions
10.1 Conformational changes
10.2 Sigmatropic shifts
10.3 Valence isomerization
10.4 Hydrogen transfer
References
Author Index
Subject Index