High-performance liquid chromatography of the drug fosinopril

✍ Scribed by Joel Kirschbaum; Joyce Noroski; Annetric Cosey; Don Mayo; John Adamovics

• Book ID: 104145611
• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 319 KB
• Volume: 507
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)84192-3

✦ Synopsis

High-performance liquid chromatography was used to determine the purity and impurities of fosinopril, an angiotensin-converting enzyme inhibitor used to treat hypertension. Purity values are determined using a silica column and usually are above 99%. All known possible impurities, including stereoisomeric impurities, can be resolved and quantified by injecting solutions of fosinopril onto three separate columns; silica, strong anion exchange and phenyl. Typical impurity contents total 0.5%. Validation data and a study of properties of fosinopril in solution is included.