✦ LIBER ✦
High performance liquid chromatography (HPLC) of natural products part VI. Sulfoxides of penicillin N and cephalosporin c and their role in biosynthesis of β-lactam antibiotics
✍ Scribed by S. Kukolja; R. D. Miller; D. C. Duckworth; D. E. Dorman; L. L. Huckstep; Norbert Neuss; S. W. Quenner
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- German
- Weight
- 348 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
Pure pencillin N α‐sulfoxide (1) and penicillin N β‐sulfoxide (2) were obtained by HPLC and tested as substrates for deacetoxycephalosporin C synthetase (DXCS). Neither one of the sulfoxides was utilized under conditions of conversion of penicillin N (8) to deacetoxycephalosporin C (9). The cephalosporin C α and β‐sulfoxides (3 and 4, resp.) were also prepared. Relative stabilities of the sulfoxides 3 and 4 are discussed by interpretation of the ^13^C‐NMR spectra.