Fluorometric high-performance liquid chr
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James J. Kinahan; Lawrence L. Samuels; Fouad Farag; Michael P. Fanucchi; Pedro M
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Article
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1985
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Elsevier Science
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English
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The antifolate compounds IOdeazaaminopterin (lOdAM) and IO-ethyl-IOdeazaaminopterin ( IO-EdAM) are therapeutically superior to methotrexate in transplanted murine tumor systems and in human tumor xenografts growing in immunodeficient "nude" mice. The increased therapeutic index of these analogs corr