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High-performance liquid chromatographic method for the analysis of 10-ethyl-10-deaza-aminopterin and metabolites in plasma

โœ Scribed by O. Van Tellingen; J.H. Beijnen; H.R. Van Der Woude; P.F. Bruning; W.J. Nooyen


Book ID
108449659
Publisher
Elsevier Science
Year
1990
Weight
563 KB
Volume
529
Category
Article
ISSN
0378-4347

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The antifolate compounds IOdeazaaminopterin (lOdAM) and IO-ethyl-IOdeazaaminopterin ( IO-EdAM) are therapeutically superior to methotrexate in transplanted murine tumor systems and in human tumor xenografts growing in immunodeficient "nude" mice. The increased therapeutic index of these analogs corr