High-performance liquid chromatographic determination of primary aromatic amines in urine after derivatization to an azo dye with 2-aminoanthracene

High-performance liquid chromatographic

High-performance liquid chromatographic determination of amantadine in urine after micelle-mediated pre-column derivatization with 1-fluoro-2,4-dinitrobenzene

✍ F.A.L. Van Der Horst; J. Teeuwsen; J.J.M. Holthuis; U.A.Th. Brinkman 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 364 KB

Cationic micelles have been used for the derivatization of the anti-Parkinson drug amantadine with the chromophore 1-fluoro-2,4-dinitrobenzene in urine. In the presence of 90 mM cetyltrimethylammonium bromide (CTAB), the conversion of amantadine into its derivative is complete within 4 min at 60 deg