High-performance liquid chromatographic determination of nitroglycerin in sublingual, sustained-release, and ointment dosage forms

✍ Scribed by Carolyn S. Olsen; Henry S. Scroggins

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 364 KB
• Volume: 72
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600720835

✦ Synopsis

A rapid, precise, sensitive, and specific assay for nitroglycerin in sublingual, sustained-release, and ointment dosage forms using high-performance liquid chromatography is described. The nitroglycerin dosage forms were dissolved in methanol, filtered, and injected directly into the liquid chromatograph. A variable-wavelength UV detector operated at 220 nm and a C18 microporous silica column were employed. The mobile phase was methanol-water (40:60).