BACKGROUND.
Attempts were made to clarify the correlation between human Tcell leukemia/lymphoma virus (HTLV-I infection and malignant oncogenicity other than adult T-cell leukemiallymphoma (ATL) in a case-control study.
METHODS.
The occurrence of primary malignant neoplasms (MN) in 110 ATL patients, their parents, and 430 siblings was compared with HTLVl seronegative non-Hodgkin's lymphoma (NHL) patients, their parents, and 867 siblings. The chi-square test, odds ratio (OR), and 95% confidence intervals (CI) were used to determine the statistical significance of differences in the occurrence of the primary MN among ATL patients, HTLV-1 seronegative NHL patients, their siblings, and their parents.
RESULTS.
The occurrence of primary MN in the ATL patients was higher than the occurrence in HTLV-1 seronegative NHL patients ( P = 0.0036; OR = 2.91; 95% CI: 1.42,6.02). In siblings of the ATL patients, there was a higher occurrence of primary MN than in siblings of the HTLV-1 seronegative NHL patients ( P < 0,0001; OR = 3.35; 95% CI: 2.01, 5.58). In mothers of the ATL patients, there was a higher occurrence of primary MN than in mothers of the HTLV-1 seronegative NHL patients ( P = 0.0063; OR = 2.55; 95% CI: 1.30, 5.00), but not in fathers ( P = 0.1602; OR = 1.68; 95% CI: 0.81, 3.47).
CONCLUSIONS.
There is an increased risk of primary MN in ATL patients, their siblings, and their mothers. Cancer 1996 781119-24.