✦ LIBER ✦

High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases

✍ Scribed by Gennaro Chiappetta; Guidalberto Manfioletti; Francesca Pentimalli; Nobutsugu Abe; Maurizio Di Bonito; Maria Teresa Vento; Ada Giuliano; Monica Fedele; Giuseppe Viglietto; Massimo Santoro; Takashi Watanabe; Vincenzo Giancotti; Alfredo Fusco

Book ID: 102673397
Publisher: John Wiley and Sons
Year: 2000
Tongue: French
Weight: 971 KB
Volume: 91
Category: Article
ISSN: 0020-7136
DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1033>3.0.co;2-v

No coin nor oath required. For personal study only.

✦ Synopsis

HMGI(Y) proteins are overexpressed in experimental and human malignancies, including colon, prostate and thyroid carcinomas. To determine at which step of the carcinogenic process HMGI(Y) induction occurs, we analysed the expression of the HMGI(Y) proteins in hyperplastic, preneoplastic and neoplastic tissues of colorectal origin by immunohistochemistry. All the colorectal carcinomas were HMGI(Y)-positive, whereas no expression was detected in normal colon mucosa tissue. HMGI(Y) expression in adenomas was closely correlated with the degree of cellular atypia. Only 2 of the 18 non-neoplastic polyps tested were HMGI(Y)-positive. These data indicate that HMGI(Y) protein induction is associated with the early stages of neoplastic transformation of colon cells and only rarely with colon cell hyperproliferation.

📜 SIMILAR VOLUMES

Analysis of high mobility group I(Y) [HM

Analysis of high mobility group I(Y) [HMGI(Y)] proteins expression in pancreatic neoplasms

✍ Abe, Nobutsugu; Watanabe, Takashi; Sugiyama, Masanori; Atomi, Yutaka 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 187 KB

Expression of the high mobility group pr

Expression of the high mobility group proteins HMGI(Y) correlates with malignant progression in Barrett metaplasia

✍ Chen, Xueyun; Lechago, Juan; Ertan, Atilla; Ergun, Gulchin; Verm, Ray; Bridges, 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 261 KB

Expression of the high-mobility group pr

Expression of the high-mobility group protein HMGI(Y) in human trophoblast: potential role in trophoblast invasion of maternal tissue

✍ Ana-Maria Bamberger; Antonis Makrigiannakis; Kerstin Röser; Jessica Radde; Tanja 📂 Article 📅 2003 🏛 Springer 🌐 English ⚖ 279 KB

Misexpression of Wild-Type and Truncated

Misexpression of Wild-Type and Truncated Isoforms of the High-Mobility Group I Proteins HMGI-C and HMGI(Y) in Uterine Leiomyomas

✍ Michael Klotzbücher; Annemarie Wasserfall; Ulrike Fuhrmann 📂 Article 📅 1999 🏛 American Society for Investigative Pathology 🌐 English ⚖ 671 KB

Activation of gene expression in human n

Activation of gene expression in human neutrophils by high mobility group box 1 protein

✍ Park, J. S.; Arcaroli, J.; Yum, H.-K.; Yang, H.; Wang, H.; Yang, K.-Y.; Choe, K. 📂 Article 📅 2003 🏛 The American Physiological Society 🌐 English ⚖ 353 KB

Expression of HMGI-C, a member of the hi

Expression of HMGI-C, a member of the high mobility group protein family, in a subset of breast cancers: Relationship to histologic grade

✍ Piere Rogalla; Klaus Drechsler; Bernd Kazmierczak; Volkhard Rippe; Ulrich Bonk; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 88 KB

The high-mobility-group (HMG) protein gene HMGI-C is apparently involved in the genesis of a variety of benign human solid tumors with rearrangements of chromosomal region 12q14-15 affecting the HMGI-C gene. So far, no expression of HMGI-C has been found in adult tissues, and no data are available o