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High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin

✍ Scribed by Yang, D.; Chen, Q.; Yang, H.; Tracey, K. J.; Bustin, M.; Oppenheim, J. J.


Book ID
126990203
Publisher
Society for Leukocyte Biology
Year
2006
Tongue
English
Weight
347 KB
Volume
81
Category
Article
ISSN
0741-5400

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## Abstract High mobility group box‐1 (HMGB‐1) is a DNA binding nuclear protein and pro‐inflammatory cytokine. The box A domain of HMGB‐1 (rHMGB‐1A) exerts an anti‐inflammatory effect, inhibiting wild‐type HMGB‐1 (wtHMGB‐1). In this study, HMGB‐1A was evaluated as an siRNA carrier with anti‐inflamm