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High Mobility Group Box 1 Protein as an Auxiliary Biomarker for Dengue Diagnosis

✍ Scribed by Allonso, D.; Vazquez, S.; Guzman, M. G.; Mohana-Borges, R.

Book ID: 120227214
Publisher: American Society of Tropical Medicine and Hygiene
Year: 2013
Tongue: English
Weight: 565 KB
Volume: 88
Category: Article
ISSN: 0002-9637
DOI: 10.4269/ajtmh.2012.12-0619

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## Abstract High mobility group box‐1 (HMGB‐1) is a DNA binding nuclear protein and pro‐inflammatory cytokine. The box A domain of HMGB‐1 (rHMGB‐1A) exerts an anti‐inflammatory effect, inhibiting wild‐type HMGB‐1 (wtHMGB‐1). In this study, HMGB‐1A was evaluated as an siRNA carrier with anti‐inflamm