๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

High level of alpha-fetoprotein in sera of adult mice

โœ Scribed by Helena Pihko; Erkki Ruoslahti

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
418 KB
Volume
12
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

Mouse aโ€fetoprotein (AFP) was purified by making use of its immunological crossโ€reaction with rabbit AFP. A radioimmunoassay, developed for mouse AFP, was used to measure AFP concentrations in the sera of adult mice of different inbred strains. The level of adult mouse AFP was found to be 30โ€“350 ng/ml, which is about 10 times higher than has been reported for humans and rats. An association seems to exist between the high basal level of AFP and the remarkably high incidence of spontaneous hepatomas in mice.

๐Ÿ“œ SIMILAR VOLUMES

Early increase of serum alpha-fetoprotei
Early increase of serum alpha-fetoprotein in spontaneous hepatocarcinogenesis in mice
โœ H. Jalanko; I. Virtanen; E. Engvall; E. Ruoslahti ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 721 KB

## Abstract The concentration of serum alphaโ€fetoprotein (AFP) was followed in C3H mice having a high incidence of spontaneous liverโ€cell cancer. No general elevation of serum AFP level with age was seen in mice without tumor. With a single exception, mice bearing hepatocellular carcinomas had incr

Alpha-fetoprotein and ฮณ-glutamyltranspep
Alpha-fetoprotein and ฮณ-glutamyltranspeptidase in mice. Effect of raf gene
โœ Hannu Jalanko ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 537 KB

## Abstract The regulation of the high physiological level of serum alphaโ€fetoprotein (AFP) in BALB/c/J mice was studied. Serum AFP concentration in 7โ€ to 12โ€weekโ€old BALB/c/J mice varied from 460 ng/ml up to 2,790 ng/ml and in other strains tested from 10 ng/ml to 400 ng/ml. In contrast to the dif