High level expression of monomeric and dimeric human α1,3-fucosyltransferase V
✍ Scribed by Jan Münster; Patrick Ziegelmüller; Edzard Spillner; Reinhard Bredehorst
- Book ID
- 118471446
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 212 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0168-1656
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## Abstract Changes in enzyme activity and the expression levels of α(1,6)fucosyltransferase [α(1,6)FT] have been reported in certain types of malignant transformations. To develop a better understanding of the role of α(1,6)FT in human colorectal carcinoma (CRC), we analysed the enzyme activity in
GDP-L-Fuc:N-acetyl--D-glucosaminide ␣1-6 fucosyltransferase (␣1-6FucT) catalyzes the transfer of a fucosyl residue from GDP-fucose to the asparagine-linked GlcNAc residue of complex N-glycans via ␣1-6 linkage. These oligosaccharide structures are essential for the attachment of polysialic acid to t