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High-level amplification of the RUNX1 gene in two cases of childhood acute lymphoblastic leukemia

✍ Scribed by Zaida García-Casado; José Cervera; Amparo Verdeguer; Maria Tasso; Ana Valencia; Juan C. Pajuelo; Armando V. Mena-Duran; Eva Barragán; Margarita Blanes; Pascual Bolufer; Miguel A. Sanz

Book ID
113512976
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
117 KB
Volume
170
Category
Article
ISSN
0165-4608

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AML1 amplification and 17q25 deletion in
AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia
✍ Tuna Gulten; Tahsin Yakut; Mutlu Karkucak; Birol Baytan; Adalet Meral Guneş 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 113 KB

## Abstract We report a case of childhood acute lymphoblastic leukemia (ALL) with both acute myeloid leukemia 1 (__AML1__) amplification and 17q25 deletion. __AML1__ gene is located on 21q22 and encodes a transcription factor. __AML1__ amplification is a common finding in childhood ALL, and itis ob