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High-Ionic Strength Interference of Ribosomal Inhibition Produced by Aminoglycoside Antibiotics

✍ Scribed by Marin, Irma; Abad, Jose P.; Urena, Dionisio; Amils, Ricardo

Book ID
125928715
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
589 KB
Volume
34
Category
Article
ISSN
0006-2960

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When DNA fragments from Micromonospora purpurea (the producer of gentamicin) were cloned in Streptomyces lividans, a gentamicin-resistant strain was obtained in which the ribosomes were highly resistant both to gentamicin and to kanamycin. Reconstitution analysis revealed that such resistance result