High interindividual restriction fragment length and copy number of polymorphism of a tvri family in moderate human DNA repeats

The human tyrosine aminotransferase gene

The human tyrosine aminotransferase gene: characterization of restriction fragment length polymorphisms and haplotype analysis in a family with tyrosinemia type II

✍ Eva-Maria Westphal; Ernst Natt; Tiemo Grimm; Michel Odievre; Gerd Scherer 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 532 KB

Deficiency in hepatic tyrosine aminotransferase (TAT) causes tyrosinemia type II, an autosomal recessively inherited disorder. Using a TAT cosmid clone, we have identified an MspI restriction fragment length polymorphism (RFLP) 5' to the TAT gene, with allele frequencies of 0.63 and 0.37. Analysis o