## Abstract In order to reveal whether differences in the type and site of __p53__ gene mutations influence the function of the gene and tumor phenotype, we examined nuclear accumulation of the p53 protein immunohistochemically, loss of the other p53 allele by restrictionβfragmentβlength polymorphi
High Incidence of p53 Gene Mutation in Human Ovarian Cancer and Its Association with Nuclear Accumulation of p53 Protein and Tumor DNA Aneuploidy
β Scribed by Kihana, Toshimasa ;Tsuda, Hitoshi ;Teshima, Shinichi ;Okada, Shuichi ;Matsuura, Shumpei ;Hirohashi, Setsuo
- Book ID
- 108579528
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1992
- Tongue
- English
- Weight
- 598 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0910-5050
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We examined the association between mutation of the p53 gene and survival in a large cohort of breast cancer patients. Using a rapid, non-isotopic single-strand conformation polymorphism (SSCP) method we screened for mutations in exons 4-10 of the p53 gene in 375 primary breast cancers from patients
The aim of this prospective study was to determine whether use of a combination of biomarkers, p53 and nuclear DNA content, led to improved prognosis and clinicopathologic correlation in human non-small cell lung cancer. Nineteen patients undergoing curative resection of p imary non-small cell lung
The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specific l