High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11)

✍ Scribed by Ilse Wieland; Petra Muschke; Marianne Volleth; Albrecht Röpke; Antje-Friederike Pelz; Markus Stumm; Peter Wieacker

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 266 KB
• Volume: 45
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.20358

✦ Synopsis

Abstract

In a family with a high incidence of postmenopausal breast cancer and a case of glioblastoma, the constitutional translocation t(11;22)(q23;q11.2) was shown to segregate with the malignancies. The breakpoints in this family coincided with the common breakpoints in t(11;22) as shown by a translocation‐specific PCR assay. Loss of heterozygosity analysis of breast tumor tissue revealed deletion of the normal chromosome 22, but retention of der(22) in the tumor cells, suggesting a predisposing effect of the der(22) for breast and brain tumor development in this family. © 2006 Wiley‐Liss, Inc.