High Incidence of Extracellular Matrix Metalloproteinase Inducer Expression in Non-Small Cell Lung Cancers
โ Scribed by Hakuma, Nobuyuki; Betsuyaku, Tomoko; Kinoshita, Ichiro; Itoh, Tomoo; Kaga, Kichizo; Kondo, Satoshi; Nishimura, Masaharu; Dosaka-Akita, Hirotoshi
- Book ID
- 121804078
- Publisher
- S. Karger AG
- Year
- 2007
- Tongue
- English
- Weight
- 433 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0030-2414
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In a comprehensive immunohistochemical study of the expression of ten metalloproteinases (MMPs) and their four inhibitors (TIMPs) in 115 non-small cell lung carcinomas (NSCLCs), the ยฎndings have been correlated with the histological and clinical features of the tumours. All MMPs and TIMPs were expre
## Abstract Matrix metalloproteinases (MMPs) are regarded as a significant regulator in tumor invasion and metastasis. Previous studies have shown that extracellular matrix metalloproteinase inducer (EMMPRIN) in tumor cells induces the synthesis of MMPs. EMMPRIN is abundantly present on the surface