High-grade dysplasia and superficial adenocarcinoma in Barrett's esophagus: histological mapping and expression of p53, p21 and Bcl-2 oncoproteins
✍ Scribed by Denis Chatelain,Jean-François Fléjou
- Book ID
- 113042109
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 492 KB
- Volume
- 442
- Category
- Article
- ISSN
- 1432-2307
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BACKGROUND. Barrett esophagus predisposes individuals to esophageal carcinoma, which develops from intermediate stages of tissue dysplasia primarily in the vicinity of the gastroesophageal junction. Understanding the cellular and molecular events in the progression of Barrett esophagus to adenocarci
## Abstract Control of the G1/S‐phase transition as well as angiogenic switch are two of the most studied mechanisms in cancer. The current study examined the correlation between the immunohistochemical expression of pRb2/p130, VEGF, EZH2, p53, p16, p21^waf‐1^, p27, and PCNA in Barrett's esophagus