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High glucose-induced upregulation of Rho / Rho-kinase via platelet-derived growth factor receptor−β increases migration of aortic smooth muscle cells

✍ Scribed by Noboru Akiyama; Keiko Naruse; Yasuko Kobayashi; Nobuhisa Nakamura; Yoji Hamada; Eitaro Nakashima; Tatsuaki Matsubara; Yutaka Oiso; Jiro Nakamura

Book ID: 116985696
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 715 KB
Volume: 45
Category: Article
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2008.04.006

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## Abstract Peritubular smooth muscle cells (PSMC) from rat testis in primary serum‐free cultures unexpectedly undergo contraction and subsequent cell hypertrophy in response to the growth factor PDGF‐BB, remaining stationary. The present study investigates the transduction pathways involved in the