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High glucose concentrations inhibit glucose phosphorylation, but not glucose transport, in human endothelial cells

✍ Scribed by Francesc Viñals; Aachim Gross; Xavier Testar; Manuel Palacı́n; Peter Rösen; Antonio Zorzano

Book ID
117351132
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
340 KB
Volume
1450
Category
Article
ISSN
0167-4889

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In an attempt to identify the mechanisms underlying the ill effects of high glucose previously described in cultured human endothelial cells, we have investigated in these cells the activity of the polyol pathway and accumulation of glucose 6-phosphate, a powerful agent of non-enzymatic glycosylatio