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High glucose and hyperosmolarity increase platelet-derived growth factor mRNA levels in cultured human vascular endothelial cells

✍ Scribed by Masakazu Mizutani; Yukichi Okuda; Takashi Yamaoka; Kenichiro Tsukahara; Masaaki Isaka; Chieko Bannai; Kamejiro Yamashita


Book ID
115765252
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
673 KB
Volume
187
Category
Article
ISSN
0006-291X

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High glucose and hyperosmolarity increas
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## Abstract Heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) has been shown to be a potent smooth muscle cell (SMC) mitogen and chemoattractant, and might be a candidate factor for the progression of atherosclerosis. We have investigated the effects of high glucose and hyperosmol