High frequency of spontaneous recurrent chromosome breakage in an untreated human tumour

The locus of the polymorphic epithelial

The locus of the polymorphic epithelial mucin (PEM) tumour antigen on chromosome 1q21 shows a high frequency of alteration in primary human breast tumours

✍ Sandra J. Gendler; Edward P. Cohen; Ann Craston; Trevor Duhig; Gillian Johnstone 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 619 KB

## Abstract Tumour and blood leukocyte DNAs from sporadic breast cancer patients were examined for chromosome 1 loss of heterozygosity using a probe for a polymorphic epithelial mucin, PEM, which is expressed in >92% of breast carcinomas as well as in normal lactating breast tissue. Expression is d