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High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire

✍ Scribed by Johan H. Van Es; Frits H. J. Gmeli Meyling; Ton Logtenberg


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
348 KB
Volume
22
Category
Article
ISSN
0014-2980

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## life* Peripheral blood B cells of a 67-year-old person were separated into IgM+IgD+, IgM+IgD-, and IgM-IgD-subsets, and nucleotide sequences of expressed immunoglobulin light chain variable (V) regions encoded by V,3 and V,4 gene family members were determined from amplified cDNA. V region sequ