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High frequency of mutations related to impaired CYP2C9 metabolism in a Caucasian population.

✍ Scribed by Elena García-Martín; Carmen Martínez; José M. Ladero; Francisco J.G. Gamito; José A.G. Agúndez


Publisher
Springer
Year
2001
Tongue
English
Weight
73 KB
Volume
57
Category
Article
ISSN
0031-6970

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Cytochrome P450 2A6 (CYP2A6) plays an important role in the oxidation of nicotine and in the activation of tobaccorelated carcinogens, such as N-nitrosodimethylamine, N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. It has been suggested that individuals with defective CYP2A