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High Frequency of Mutations of the PIK3CA Gene in Human Cancers

✍ Scribed by Samuels, Yardena (author);Wang, Zhenghe (author);Bardelli, Alberto (author);Silliman, Natalie (author);Ptak, Janine (author);Szabo, Steve (author);Yan, Hai (author);Gazdar, Adi (author);Powell, Steven M. (author);Riggins, Gregory J. (author);Willson, James K.V. (author);Markowitz, Sanford (author);Kinzler, Kenneth W. (author);Vogelstein, Bert (author);Velculescu, Victor E. (author)

Book ID
111962596
Publisher
American Association for the Advancement of Science
Year
2004
Tongue
English
Weight
62 KB
Volume
304
Category
Article
ISSN
0036-8075

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## Abstract Somatic mutations of the __PIK3CA__ gene have recently been detected in various human cancers, including sporadic colorectal cancer. However, mutations of the __PIK3CA__ gene in hereditary colorectal cancers have not been clarified. To elucidate the mutation status in familial adenomato