Analysis of a non-functional HNF-1α (TCF
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Issei Yoshiuchi; Kazuya Yamagata; Masaaki Yoshimoto; Qian Zhu; Qin Yang; Takao N
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Article
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2001
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John Wiley and Sons
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English
⚖ 380 KB
Mutations in the transcription factor hepatocyte nuclear factor-1a (HNF-1a; gene symbol TCF1) cause maturity-onset diabetes of the young type 3 (MODY3), a form of diabetes mellitus characterized by autosomal dominant inheritance, early onset, and pancreatic b-cell dysfunction. Recent genetic studies