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High frequency of CD8αα homodimer-bearing T cells in human fetal intestine

✍ Scribed by Manish Latthe; Linda Terry; Thomas T. Macdonald

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
392 KB
Volume
24
Category
Article
ISSN
0014-2980

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✦ Synopsis

High frequency of CDSaa homodimer-bearing T cells in human fetal intestine*

Immunohistochemistry on frozen sections was used to identify CD8au cells and CD8ap cells in human intestine. As observed previously, CD8a13 cells predominate (>95%) in tonsil and post-natal intestine. However in human fetal intestine (16-24 weeks gestation), almost half the CD8+ cells in the lamina propria are CDSaa, and many CD8aacells can be identified in the epithelium. In contrast. in the T cell zones of the Peyer's patches, CD8aP cells are dominant. The CDXau cells are virtually all uP T cell receptor positive. By analogy with the murine system, these CD8aa cells in the fetal gut may be directly derived from the marrow, undergoing thymus-independent differentiation in the gut mucosa.

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