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High-Frequency DNA Rearrangements in the Chromosomes of Clinically IsolatedMycoplasma fermentans

โœ Scribed by Wensi S. Hu; Michael M. Hayes; Richard Yuan-Hu Wang; James Wai-Kuo Shih; Shyh-Ching Lo

Book ID
105998062
Publisher
Springer
Year
1998
Tongue
English
Weight
470 KB
Volume
37
Category
Article
ISSN
0343-8651

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Genes and genomes: High-frequency induct
Genes and genomes: High-frequency induction of chromosomal rearrangements in mouse germ cells by the chemotherapeutic agent chlorambucil
โœ Eugene M. Rinchik; Lorraine Flaherty; Liane B. Russell ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 745 KB

Recent mutagenesis studies have demonstrated that the chemotherapeutic agent, chlorambucil (CHL), is highly mutagenic in male germ cells of the mouse. Post-meiotic germ cells, and especially early spermatids, are the most sensitive to the cytotoxic and mutagenic effects of this agent. Genetic, cytog