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High fidelity of whole-genome amplified DNA on high-density single nucleotide polymorphism arrays

✍ Scribed by Jinchuan Xing; W. Scott Watkins; Yuhua Zhang; David J. Witherspoon; Lynn B. Jorde


Book ID
116981808
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
518 KB
Volume
92
Category
Article
ISSN
0888-7543

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Whole-genome DNA amplification by multiple displacement (MD-WGA) is a promising tool to obtain sufficient DNA amounts from samples of limited quantity. Using Affymetrix' GeneChip Human Mapping 10K Arrays, we investigated the accuracy and allele amplification bias in DNA samples subjected to MD-WGA.