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High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma

✍ Scribed by Yuko Kamata; Jun Watanabe; Yukari Nishimura; Tsutomu Arai; Miwa Kawaguchi; Manabu Hattori; Akane Obokata; Hiroyuki Kuramoto

Publisher: Springer-Verlag
Year: 2005
Tongue: English
Weight: 484 KB
Volume: 131
Category: Article
ISSN: 1432-1335
DOI: 10.1007/s00432-005-0671-2

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## Abstract ## BACKGROUND The p53‐dependent G2/M checkpoint plays a key role in the maintenance of genomic integrity, thereby protecting cells from neoplastic progression. __Reprimo__, a gene involved in the p53‐induced G2 cell cycle arrest, has been recently identified as a novel target for aberr