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High expression of MHC I in the tibialis anterior muscle of a paraplegic patient

✍ Scribed by Andreas Hartkopp; Jesper L. Andersen; Stephen D.R. Harridge; Clarissa Crone; Tom Gruschy-Knudsen; Michael Kjær; Mizuno Masao; Aivaras Ratkevicius; Bjørn Quistorff; Shi Zhou; Fin Biering-Sørensen

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
344 KB
Volume
22
Category
Article
ISSN
0148-639X

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✦ Synopsis

A long-term paraplegic man presented exclusively (>99%) myosin heavy chain I (MHC I) in the tibialis anterior muscle (TA). This was coupled to a slow speed of contraction, a high resistance to fatigue, and a rapid resynthesis of phosphocreatine after an electrically evoked fatiguing contraction when compared with the TA muscles of 9 other paraplegic individuals. In contrast, the MHC composition of his vastus lateralis, gastrocnemius, and soleus muscles was that expected of a muscle from a spinal cord injured individual. This information may be of clinical importance in terms of the expected morphological and functional adaptations of skeletal muscle to different types of electrical stimulation therapy.

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