High-energy phosphate compounds and some glycolytic substrates in the rat brain during hypoxia

✍ Scribed by Barbara Broniszewska-Ardelt; Marianna Sikorska

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 231 KB
• Volume: 4
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490040404

✦ Synopsis

Abstract

The influence of acute and prolonged (with resuscitation) hypoxia, upon some glycolytic substrates and high energy phosphate compounds in the rat brain, was studied. Acute hypoxia decreased the content of glucose and glucose‐6‐phosphate as well as of high energy phosphate compounds. Simultaneously, an increase of lactic acid level was recorded.

Some adaptation features could be observed, when 30‐minute hypoxia with resuscitation was studied. Brain content of high energy compounds returned to the normal value, while that of glucose increased twice over control. However, the level of lactic acid was still increased.