High-dose versus low-dose CMFP regimen in advanced breast cancer

✍ Scribed by Anand Kumar; N. N. Khanna; C. C. Pant; S. Khanna

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 240 KB
• Volume: 25
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930250417

✦ Synopsis

Fifty cases of advanced breast cancer (stages III and IV) were treated by combination chemotherapy. The study compares the two different dose schedules and toxicities of a combination of cyclophosphamide, methotrexate, 5-flurouracil, and prednisone. Results are better with high-dose regimen, though the incidence of toxicity is much as compared to low-dose schedules, but, considering the beneficial response, the high-dose schedule is recommended.