## Germ -cell tumors (GCTs) are very chemosensitive and highly curable cancers. For the small proportion of patients who fail conventional chemotherapy (CT), high-dose CT (HDCT) was introduced in France and elsewhere in 1982-1984. We report here on the French experience with HDCT in GCTs. At the C
High-dose salvage chemotherapy. Germ-cell tumor treatment results in Germany
✍ Scribed by Oliver Rick; Wolfgang Siegert; Jörg Beyer
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 65 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
During the past 10 years, high-dose chemotherapy (HDCT) has emerged as a feasible and curative treatment option for patients with multiply relapsed and/or refractory germ-cell tumors. Increasing experience and the results from clincial trials have helped to optimize the application of HDCT and to define its role in the salvage concepts for germ-cell tumors.
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Although the majority of patients with poor-risk germ-cell tumors (GCTs) will achieve a durable complete remission (CR) with standard first-line therapy, 20% to 30% of them will either relapse or fail to achieve an initial CR and eventually die. For this reason, the strategy of using high-dose (HD)
## BACKGROUND. The optimal treatment of patients with recurrent or refractory germ