High dose of glucose promotes chondrogenesis via PKCα and MAPK signaling pathways in chick mesenchymal cells

High glucose regulates cyclin D1/E of hu

High glucose regulates cyclin D1/E of human mesenchymal stem cells through TGF-β1 expression via Ca2+/PKC/MAPKs and PI3K/Akt/mTOR signal pathways

✍ Jung Min Ryu; Min Young Lee; Seung Pil Yun; Ho Jae Han 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 554 KB

## Abstract The elucidation of factors that support human mesenchymal stem cells (hMSCs) growth has remained unresolved partly because of the reliance of many researchers on ill‐defined, proprietary medium formulation. Thus, we investigated the effects of high glucose (D‐glucose, 25 mM) on hMSCs pr