✦ LIBER ✦

High dose methotrexate followed by citrovorum factor reversal in patients with advanced cancer

✍ Scribed by Edward P. Ambinder; Marjorie Perloff; Takao Ohnuma; Hugh F. Biller; James F. Holland

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 506 KB
Volume: 43
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197904)43:4<1177::aid-cncr2820430403>3.0.co;2-r

No coin nor oath required. For personal study only.

✦ Synopsis

High dose methotrexate followed by citrovorum factor reversal has been utilized in twenty-six patients with advanced cancer. Four of 10 patients with head and neck cancer had an objective response. One of 7 patients with metastatic osteosarcoma to the lungs had stabilization with twenty treatments over 23 months. One patient with acute lymphocytic leukemia developed marrow aplasia but did not attain remission. The regimen was well tolerated when meticulous attention was paid to hydration, urine alkalinization, renal function and third space fluid accumulation. Life-threatening or lethal toxicity was encountered when these phenomena were not scrupulously observed.

📜 SIMILAR VOLUMES

High dose methotrexate with citrovorum f

High dose methotrexate with citrovorum factor in adult resistant lymphoma

✍ Steven Turman; Morton Coleman; Richard T. Silver; Mark Pasmantier 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 470 KB 👁 3 views

High-dose methotrexate with citrovorum f

High-dose methotrexate with citrovorum factor and vincristine in the treatment of malignant mesothelioma

✍ Nikolay V. Dimitrov; James Egner; Ernie Balcueva; Leif G. Suhrland 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 272 KB 👁 3 views

The incidence of malignant mesothelioma has increased greatly in the last 40 years. Current and recent past exposure to asbestos is expected to substantially increase this incidence. We report nine cases of malignant mesothelioma which temporarily responded to treatment with high-dose methotrexate-c

Sequential chemotherapy of advanced colo

Sequential chemotherapy of advanced colorectal cancer with standard or high-dose methotrexate followed by 5-fluorouracil

✍ Solan, Andrew ;Vogl, Steven E. ;Kaplan, Barry H. ;Berenzweig, Marc ;Richard, Jos 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB

## Abstract Thirty patients with advanced measurable colorectal cancer were randomized to receive either methotrexate (MTX) 200 mg/m^2^ or 40 mg/m^2^, followed in four hours by 5‐fluorouracil (5‐FU) 600 mg/m^2^. Patients receiving the higher dose MTX were given leucovorin rescue 24 hours later. Eig

Oral high-dose methotrexate with citrovo

Oral high-dose methotrexate with citrovorum factor rescue in metastatic squamous cell carcinoma of the lung

✍ Karl Tornyos; Hiltrud Faust 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB 👁 3 views

The safety of administration of massive

The safety of administration of massive doses of methotrexate (50 g) with equimolar citrovorum factor rescue in adult patients

✍ Avner Reggev; Isaac Djerassi 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 634 KB

High dose radiochemotherapy followed by

High dose radiochemotherapy followed by autologous stem cell transplantation in four patients with multiple lymphomatous polyposis

✍ Béatrice Mahé; Anne Moreau; Philippe Moreau; Stéphane Le Tortorec; Jean-Luc Haro 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 472 KB 👁 2 views

## Background: Multiple lymphomatous polyposis (mlp) results from gastrointestinal involvement by a b-cell lymphoma that originates from the mantle zone of lymphoid follicles. this well described clinicopathologic entity has a poor prognosis: the rate of complete response after conventional chemoth