𝔖 Bobbio Scriptorium
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High dose mesna may interfere with the antitumour activity of ifosfamide

✍ Scribed by E. A. Wist; S. Aamdal; Ø. P. Solheim

Book ID
112785336
Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
136 KB
Volume
111
Category
Article
ISSN
1432-1335

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✍ Robin C. Stuart-Harris; Peter G. Harper; Colin A. Parsons; Stanley B. Kaye; Caro 📂 Article 📅 1983 🏛 Springer 🌐 English ⚖ 463 KB

In a phase II study, 42 patients with advanced soft-tissue sarcoma were treated with ifosfamide by 24-h infusion and mesna by 4-h IV bolus, repeated every 3 weeks. Ten patients received ifosfamide 5.0 g/m2, 20 had the dosage increased to 8.0 g/m2, and 12 received 8.0 g/m2 from the outset. Mesna was