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High-dose intravenous IgG for chronic idiopathic thrombocytopenic purpura in adults

✍ Scribed by Lang, J. M. ;Faradji, A. ;Giron, C. ;Bergerat, J. P. ;Oberling, F.

Publisher
Springer-Verlag
Year
1984
Weight
271 KB
Volume
49
Category
Article
ISSN
1432-0584

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✦ Synopsis

Sixteen adult patients of mean age 48 years with chronic ITP were studied for platelet response to high-dose (0.4 g/kg body weight per day for five consecutive days) intravenous polyvalent intact IgG in the absence of any concurrent treatment. The platelet count returned to normal values in nine patients, a partial response (rise in the platelet count between 50 and 150 Γ— 109/1) was observed in three cases. One patient refractory to any other treatment went into a sustained remission. In the other responsive patients the response was only transient. Among seven splenectomised patients only three responded to IgG infusions versus nine in the non-splenectomised group. The length of ITP history appeared as a more critical factor for the response to IgG than previous splenectomy.

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