## Background: Durable complete response rates ranging from 5% to 20% have been reported in association with biochemotherapy for patients with metastatic melanoma, with response rates on the low end of this range being observed in trials that used lower doses and less intense treatment schedules. i
High-dose-intensity combination chemotherapy for advanced sarcomas: a pilot study
โ Scribed by Paolo Pronzato; Pierluigi Losardo; Floriana Pensa; Alessandra Tognoni
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 262 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0344-5704
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A total of 144 patients with advanced sarcomas were entered into a randomized prospective protocol with four treatment arms utilizing different combinations of chemotherapeutic agents. Of these, 120 patients (83%) were judged acceptable. Treatment #1: actinomycin-D (Act-D), 0.01 mg/kg IV, days 1-5;
## Abstract Eight patients with advanced/recurrent retinoblastomas were treated with sequential combination chemotherapy incorporating cyclophosphamide, cisplatin, adriamycin, and etoposide. All patients achieved complete clinical response (CR) at the end of the first 75 day cycle. Three patients d
Pilot studies were conducted to evaluate the toxicity and efficacy of two relatively marrow-sparing chemotherapy regimens in the treatment of advanced or progressive epidemic Kaposi's sarcoma. Chemotherapy regimens consisted of bleomycin (10 mg/m2), vincristine (1.4 mg/m2, 2 mg maximum) and Adriamyc