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High-dose cyclophosphamide with autologous marrow transplantation as initial treatment of small cell carcinoma of the bronchus

โœ Scribed by R. L. Souhami; P. G. Harper; D. Linch; C. Trask; A. H. Goldstone; J. Tobias; S. G. Spiro; D. M. Geddes; J. D. M. Richards

Publisher
Springer
Year
1982
Tongue
English
Weight
313 KB
Volume
8
Category
Article
ISSN
0344-5704

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โœฆ Synopsis

Sixteen patients with untreated small cell carcinoma of the bronchus received cyclophosphamide in a total dose of 160-200 mg/kg. Autologous marrow transplantation was used to minimise the period of hypoplasia and 2-mercaptoethane sulphonate to prevent urothelial toxicity. The procedure was well tolerated, with predictable and manageable toxicity. Complete radiological and bronchoscopic response was achieved in seven patients and partial response in a further seven. High-dose cyclophosphamide may be a useful initial treatment for this disease.

๐Ÿ“œ SIMILAR VOLUMES

High-dose cyclophosphamide with autologo
High-dose cyclophosphamide with autologous marrow transplantation for small cell carcinoma of the bronchus
โœ Robert L. Souhami; Peter G. Harper; David Linch; Colin Trask; Anthony H. Goldsto ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 323 KB

Twenty-five patients with previously untreated small cell carcinoma of the bronchus have been treated with cyclophosphamide 160-200 mg/kg and subsequent radiotherapy to the primary site. Eighty-four percent of patients responded to the single cycle of chemotherapy, with 56% attaining a complete resp