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High-dose 5-fluorouracil plus low dose methotrexate plus or minus low-dose PALA in advanced colorectal cancer: a randomised phase II-III trial of the EORTC Gastrointestinal Group

✍ Scribed by J Wils; G.H Blijham; Th Wagener; J De Greve; R.L.H Jansen; T.C Kok; J.W.R Nortier; H Bleiberg; M.L Couvreur; B Genicot; B Baron


Book ID
117659199
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
153 KB
Volume
39
Category
Article
ISSN
0959-8049

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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer