High-diversity combinatorial libraries

✍ Scribed by Lutz Weber

• Book ID: 104414426
• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 186 KB
• Volume: 4
• Category: Article
• ISSN: 1367-5931
• DOI: 10.1016/s1367-5931(00)00092-2

✦ Synopsis

The synthesis of complex chemical structures by combinatorial chemistry has gained considerable interest. New chemical methods have been developed that enable the synthesis of compound libraries exhibiting structural diversities similar to those of natural products. The concept of 'chemical genomics' has been introduced, reflecting a new quality of understanding and creating the relationship between diverse artificial chemical structures with the space of biological responses and possible protein ligands.