High Density Lipoproteins From Biologica
β Kardassis, Dimitris;Von Eckardstein, Arnold
π Library
π
2015
π Springer International Publishing
π English
β¦ LIBER β¦
π
High Density Lipoproteins: From Biological Understanding to Clinical Exploitation
β Scribed by Arnold von Eckardstein, Dimitris Kardassis (eds.)
- Publisher
- Springer International Publishing
- Year
- 2015
- Tongue
- English
- Leaves
- 694
- Series
- Handbook of Experimental Pharmacology 224
- Edition
- 1
- Category
- Library
β¬ Acquire This Volume
No coin nor oath required. For personal study only.
β¦ Synopsis
In this Handbook of Experimental Pharmacology on βHigh Density Lipoproteins β from biological understanding to clinical exploitationβcontributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation.
The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
β¦ Table of Contents
Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Structure of HDL: Particle Subclasses and Molecular Components....Pages 3-51
HDL Biogenesis, Remodeling, and Catabolism....Pages 53-111
Regulation of HDL Genes: Transcriptional, Posttranscriptional, and Posttranslational....Pages 113-179
Cholesterol Efflux and Reverse Cholesterol Transport....Pages 181-206
Functionality of HDL: Antioxidation and Detoxifying Effects....Pages 207-228
Signal Transduction by HDL: Agonists, Receptors, and Signaling Cascades....Pages 229-256
Front Matter....Pages 257-257
Epidemiology: Disease Associations and Modulators of HDL-Related Biomarkers....Pages 259-283
Beyond the Genetics of HDL: Why Is HDL Cholesterol Inversely Related to Cardiovascular Disease?....Pages 285-300
Mouse Models of Disturbed HDL Metabolism....Pages 301-336
Dysfunctional HDL: From Structure-Function-Relationships to Biomarkers....Pages 337-366
Front Matter....Pages 367-367
HDL and Atherothrombotic Vascular Disease....Pages 369-403
HDLs, Diabetes, and Metabolic Syndrome....Pages 405-421
High-Density Lipoprotein: Structural and Functional Changes Under Uremic Conditions and the Therapeutic Consequences....Pages 423-453
Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions....Pages 455-482
HDL in Infectious Diseases and Sepsis....Pages 483-508
High-Density Lipoproteins in Stroke....Pages 509-526
Therapeutic Potential of HDL in Cardioprotection and Tissue Repair....Pages 527-565
Front Matter....Pages 567-567
HDL and Lifestyle Interventions....Pages 569-592
Effects of Established Hypolipidemic Drugs on HDL Concentration, Subclass Distribution, and Function....Pages 593-615
Emerging Small Molecule Drugs....Pages 617-630
Front Matter....Pages 567-567
ApoA-I Mimetics....Pages 631-648
Antisense Oligonucleotides, microRNAs, and Antibodies....Pages 649-689
Back Matter....Pages 691-694
β¦ Subjects
Pharmacology/Toxicology; Molecular Medicine; Human Physiology; Immunology; Cell Biology
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