High-density lipoprotein subfractions in normolipidemic individuals without clinical atherosclerosis lipoprotein subfractions in an adult population
✍ Scribed by Fabio L. Sodré; Vera S. Castanho; Lucia N. Castilho; Silvia de Barros-Mazon; Eliana C. de Faria
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 122 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0887-8013
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✦ Synopsis
This study evaluated the serum concentrations of lipids, lipoproteins, apolipoproteins, and high-density lipoprotein (HDL) subfractions in Brazilian adults. We analyzed the distribution of lipids in HDL 2 and HDL 3 in a normolipidemic population without evidence of established cardiovascular disease (CVD). A total of 93 males and 92 females, healthy and normolipidemic, volunteered to be submitted to a clinical examination, a blood collection, and to answer a questionnaire aimed at determining signs and symptoms of atherosclerotic disease. Their fasting plasma lipid, lipoproteins, apolipoproteins, and the cholesterol and triglyceride concentrations in HDL 2 and HDL 3 , isolated by microultracentrifugation, were determined by enzymatic-colorimetric methods. The interpercentile intervals (2.5-97.5) for the population were established as being 5-18 mg/dL in men and 4-28 mg/dL in women for HDL 2 cholesterol (HDL 2 chol) and 1-57 mg/dL in men and 2-61 mg/dL in women for HDL 3 cholesterol (HDL 3 chol). HDL 2 triglyceride levels (HDL 2 Tg) in men were 1-26 mg/dL and in women 2-28 mg/dL; moreover, the HDL 3 triglyceride (HDL 3 Tg) intervals were established as 4-46 mg/dL for both sexes. The determination of reference ranges for lipids in HDL subfractions in populations without clinical atherosclerosis, is an useful tool for metabolic, diagnostic, and therapeutic approaches. We determined the intervals for HDL 2 chol, HDL 3 chol, HDL 2 Tg, and HDL 3 Tg. There were variations with sex and/or age for HDL 2 chol, HDL 3 chol, and HDL 2 Tg in the studied population.