High cholesterol diet supplemented with sunflower seed oil but not olive oil stimulates lipid peroxidation in plasma, liver, and aorta of rats
✍ Scribed by Hüseyin Bulur; Gül Özdemirler; Büge Öz; Gülçin Toker; Muzaffer Öztürk; Müjdat Uysal
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 460 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0955-2863
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✦ Synopsis
To determine the effect of a high cholesterol diet supplemented with sunflower seed oil or olive oil on plasma, liver, and aorta lipid peroxi~tion, rats were fed a basal diet, a high cholesterol diet (basal diet rontaining 2% cholesterol and 0.5% cholic acid), or a high cholesterol diet supplemented with 10% (wtiwt} sunflower seed oil or 10% (wtlwt) olive oil for 4 months. In rats fed the high cholesterol diet supplemented with sunflower seed oil, plasma, liver, and aorta lipid peroxide levels and the aorta cholesterol to phospholipid ratio were greater than in rats fed the high cholesterol diet. In contrast, no change was observed in plasma, liver, and aorta lipid peroxidation and the cholesterol to phospholipid ratio in rats fed the high cholesterol diet containing olive oil as compared with the high cholesterol diet. In addition, atherosclerotic lesions were not detected in the aorta of all groups. We concluded that a high cholesterol diet supplemented with polyunsaturated fats, but not wi#h monounsaturated fats, seems to have a tendency to exaggerate lipid peroxidation. (J. Nun. Biochem. 6547-550 1995.