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High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

✍ Scribed by Gladys S Ingle; Pamela Chan; J Michael Elliott; Wesley S Chang; Hartmut Koeppen; Jean-Philippe Stephan; Suzie J Scales

Book ID
118700120
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
565 KB
Volume
0
Category
Article
ISSN
0007-1048

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## Abstract CD30 is selectively expressed on the tumor cells of a variety of malignant disorders of the immune system and can therefore be used as a target for an anti‐CD30 antibody‐based immunotherapy. However, CD30 is cleaved at the cell surface by tumor necrosis factor‐α converting enzyme (TACE)