High-affinity recombinant antibodies against neovasculature and extra-cellular matrix antigens : Dario Neria, Greg Wintera, Lorenza Wyderb, Roman Klemenzb, Giovanni Neric, Alessandro Pinic, Roberta Bottic, Paolo Neric, Patrixia Castellanid, Barbara Carnemollad, Luciano Zardid, aCambridge Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK, bInstitute of Pathology and Internal Medicine, Division of Molecular Medicine, University Hospital Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland, cDipartimento di Biologia Molecolare, Sczione di Immunochimica, Universita' di Siena, Loc. Le Scotte, 53100 Siena, Italy, dLaboratory of Cell Biology, Istituto Nazionale per la Ricerca sul Cancro, L.go Rossana Benzi 10, 16132 Genova, Italy